Open AccessChanges in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice
Author(s) -
Yuhai Bi,
Haixia Xiao,
Quanjiao Chen,
Yan Wu,
Lifeng Fu,
Chuansong Quan,
Gary Wong,
Jun Liu,
Joel Haywood,
Yingxia Liu,
Boping Zhou,
Jinghua Yan,
Wenjun Liu,
George F. Gao
Publication year - 2015
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02553-15
Subject(s) - stalk , biology , neuraminidase , virulence , infectivity , virus , virology , amino acid , influenza a virus , viral replication , gene , microbiology and biotechnology , genetics , horticulture
The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replicationin vitro orin vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
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