Open AccessLytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes
Author(s) -
Florian Bihl,
Murli Narayan,
John V. Chisholm,
Leah M. Henry,
Todd J. Suscovich,
Elizabeth E. Brown,
Tania M. Welzel,
Daniel E. Kaufmann,
Tauheed Zaman,
Sheila C. Dollard,
Jeff Martin,
Fred Wang,
David T. Scadden,
Kenneth M. Kaye,
Christian Brander
Publication year - 2007
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02509-06
Subject(s) - lytic cycle , biology , virology , epitope , antigen , kaposi's sarcoma associated herpesvirus , immune system , epstein–barr virus , virus , gammaherpesvirinae , herpesviridae , phenotype , cellular immunity , human leukocyte antigen , immunology , genetics , gene , viral disease
The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
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