Vesicular Stomatitis Virus-Based H5N1 Avian Influenza Vaccines Induce Potent Cross-Clade Neutralizing Antibodies in Rhesus Macaques | Zendy

Jennifer A. Schwartz | Zendy; Linda Buonocore | Zendy; Amorsolo L. Suguitan | Zendy; Meredith Hunter | Zendy; Preston A. Marx | Zendy; Kanta Subbarao | Zendy; John K. Rose | Zendy

Open Access

Vesicular Stomatitis Virus-Based H5N1 Avian Influenza Vaccines Induce Potent Cross-Clade Neutralizing Antibodies in Rhesus Macaques

Author(s) -

Jennifer A. Schwartz,

Linda Buonocore,

Amorsolo L. Suguitan,

Meredith Hunter,

Preston A. Marx,

Kanta Subbarao,

John K. Rose

Publication year - 2011

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.02491-10

Subject(s) - virology , biology , vesicular stomatitis virus , hemagglutinin (influenza) , influenza a virus subtype h5n1 , neutralizing antibody , heterologous , vesicular stomatitis , virus , antibody , strain (injury) , rhabdoviridae , neutralization , gene , immunology , genetics , anatomy

We analyzed the ability of a vaccine vector based on vesicular stomatitis virus (VSV) to induce a neutralizing antibody (NAb) response to avian influenza viruses (AIVs) in rhesus macaques. Animals vaccinated with vectors expressing either strain A/Hong Kong/156/1997 or strain A/Vietnam/1203/2004 H5 hemagglutinin (HA) were able to generate robust NAb responses. The ability of the vectors to induce NAbs against homologous and heterologous AIVs after a single dose was dependent upon the HA antigen incorporated into the VSV vaccine. The vectors expressing strain A/Vietnam/1203/2004 H5 HA were superior to those expressing strain A/Hong Kong/156/1997 HA at inducing cross-clade NAbs.

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