Open AccessVesicular Stomatitis Virus-Based H5N1 Avian Influenza Vaccines Induce Potent Cross-Clade Neutralizing Antibodies in Rhesus Macaques
Author(s) -
Jennifer A. Schwartz,
Linda Buonocore,
Amorsolo L. Suguitan,
Meredith Hunter,
Preston A. Marx,
Kanta Subbarao,
John K. Rose
Publication year - 2011
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.02491-10
Subject(s) - virology , biology , vesicular stomatitis virus , hemagglutinin (influenza) , influenza a virus subtype h5n1 , neutralizing antibody , heterologous , vesicular stomatitis , virus , antibody , strain (injury) , rhabdoviridae , neutralization , gene , immunology , genetics , anatomy
We analyzed the ability of a vaccine vector based on vesicular stomatitis virus (VSV) to induce a neutralizing antibody (NAb) response to avian influenza viruses (AIVs) in rhesus macaques. Animals vaccinated with vectors expressing either strain A/Hong Kong/156/1997 or strain A/Vietnam/1203/2004 H5 hemagglutinin (HA) were able to generate robust NAb responses. The ability of the vectors to induce NAbs against homologous and heterologous AIVs after a single dose was dependent upon the HA antigen incorporated into the VSV vaccine. The vectors expressing strain A/Vietnam/1203/2004 H5 HA were superior to those expressing strain A/Hong Kong/156/1997 HA at inducing cross-clade NAbs.