Surface Glycoproteins of an African Henipavirus Induce Syncytium Formation in a Cell Line Derived from an African Fruit Bat, Hypsignathus monstrosus | Zendy

Nadine Krüger | Zendy; Markus Hoffmann | Zendy; Michael Weis | Zendy; Jan Felix Drexler | Zendy; Marcel A. Müller | Zendy; Christine Winter | Zendy; Victor M. Corman | Zendy; Tim Gützkow | Zendy; Christian Drosten | Zendy; Andrea Maisner | Zendy; Georg Herrler | Zendy

Open Access

Surface Glycoproteins of an African Henipavirus Induce Syncytium Formation in a Cell Line Derived from an African Fruit Bat, Hypsignathus monstrosus

Author(s) -

Nadine Krüger,

Markus Hoffmann,

Michael Weis,

Jan Felix Drexler,

Marcel A. Müller,

Christine Winter,

Victor M. Corman,

Tim Gützkow,

Christian Drosten,

Andrea Maisner,

Georg Herrler

Publication year - 2013

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.02458-13

Subject(s) - syncytium , biology , glycoprotein , tropism , virology , tissue tropism , virus , genetics

Serological screening and detection of genomic RNA indicates that members of the genusHenipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat,Hypsignathus monstrosus . Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.

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