Batai and Ngari Viruses: M Segment Reassortment and Association with Severe Febrile Disease Outbreaks in East Africa | Zendy

Thomas Briese | Zendy; Brian H. Bird | Zendy; Vishal Kapoor | Zendy; Stuart T. Nichol | Zendy; W. Ian Lipkin | Zendy

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Batai and Ngari Viruses: M Segment Reassortment and Association with Severe Febrile Disease Outbreaks in East Africa

Author(s) -

Thomas Briese,

Brian H. Bird,

Vishal Kapoor,

Stuart T. Nichol,

W. Ian Lipkin

Publication year - 2006

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.02448-05

Subject(s) - orthobunyavirus , outbreak , virology , biology , virus , reassortment , bunyaviridae , orbivirus , reoviridae , disease , infectious disease (medical specialty) , medicine , covid-19 , pathology , rotavirus

Ngari virus is an orthobunyavirus recently recognized as a reassortant between Bunyamwera virus and an as yet unidentified M segment donor. Analysis of M segment sequences of Batai and Ilesha viruses revealed 95% deduced amino acid identity between Batai virus and Ngari virus. These findings suggest Batai virus as the donor of Ngari virus M segment sequence. Analysis of Batai virus-related African isolates identified UgMP-6830, isolated from mosquitoes in Uganda, as an isolate of Batai virus. KV-141, isolated during a febrile disease outbreak in Sudan, was identified as another isolate of Ngari virus, emphasizing a role of this reassortant virus in severe human illness throughout East Africa.

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