Open AccessMicroglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice
Author(s) -
Gema Olivarria,
Yu-Ting Cheng,
Susana Furman,
Collin Pachow,
Lindsay A. Hohsfield,
Charlene Smith-Geater,
Ricardo Miramontes,
Jie Wu,
Mara S Burns,
Kate I Tsourmas,
Jennifer Stocksdale,
Cynthia Manlapaz,
William H. Yong,
John R. Teijaro,
Robert A. Edwards,
Kim N. Green,
Leslie Thompson,
Thomas E. Lane
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01969-21
Subject(s) - biology , chemokine , viral replication , microglia , virology , proinflammatory cytokine , virus , immunology , cytokine , cxcl10 , immune system , inflammation
Understanding the immunological mechanisms contributing to both host defense and disease following viral infection of the CNS is of critical importance given the increasing number of viruses that are capable of infecting and replicating within the nervous system. With this in mind, the present study was undertaken to evaluate the role of microglia in aiding in host defense following experimental infection of the central nervous system (CNS) of K18-hACE2 with SARS-CoV-2, the causative agent of COVID-19.