Open AccessContribution of Neuraminidase to the Efficacy of Seasonal Split Influenza Vaccines in the Ferret Model
Author(s) -
Miruna E. Rosu,
Adinda Kok,
Theo M. Bestebroer,
Dennis de Meulder,
Elwin P Verveer,
Mark Pronk,
Lennard J. M. Dekker,
Theo M. Luider,
Mathilde Richard,
Judith M. A. van den Brand,
Ron A. M. Fouchier,
Sander Herfst
Publication year - 2022
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01959-21
Subject(s) - biology , virology , neuraminidase , vaccination , virus , antigenic drift , heterologous , antigen , hemagglutinin (influenza) , antibody , antigenic variation , influenza vaccine , titer , homologous chromosome , vaccine efficacy , microbiology and biotechnology , immunology , biochemistry , gene
Despite the availability of vaccines, influenza virus infections continue to cause substantial morbidity and mortality in humans. Currently available influenza vaccines take primarily the hemagglutinin (HA) into account, but the highly variable nature of this protein as a result of antigenic drift has led to a recurrent decline in vaccine effectiveness.