Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction | Zendy

Giulia Torriani | Zendy; Clara Galan-Navarro | Zendy; Stefan Kunz | Zendy

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Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

Author(s) -

Giulia Torriani,

Clara Galan-Navarro,

Stefan Kunz

Publication year - 2016

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01902-16

Subject(s) - arenavirus , biology , lassa virus , viral entry , virus , virology , lassa fever , endosome , host (biology) , endocytosis , ebola virus , viral envelope , cell , lymphocytic choriomeningitis , viral replication , immune system , immunology , genetics , cd8

Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.

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