Open AccessAntibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain
Author(s) -
Sol Ferrero,
Maria Flóres,
Connor Short,
Cecilia Vázquez,
Lars Clark,
James Ziegenbein,
Samantha Zink,
Daniel Fuentes,
Cristian Payés,
María V Batto,
Michael Collazo,
Cybele C. Garcı́a,
Jonathan Abraham,
Sandra M. Cordo,
José A. Rodríguez,
Gustavo Helguera
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01868-20
Subject(s) - ectodomain , biology , arenavirus , virology , junin virus , monoclonal antibody , virus , antibody , antigen , biochemistry , lymphocytic choriomeningitis , receptor , genetics , cd8
Pathogenic clade B NWMs cause grave infectious diseases, the South American hemorrhagic fevers. Their etiological agents are Junin (JUNV), Guanarito (GTOV), Sabiá (SABV), Machupo (MACV), Chapare (CHAV), and a new Sabiá-like (SABV-L) virus recently identified in Brazil.