Open AccessChloroquine Administration Does Not Prevent Nipah Virus Infection and Disease in Ferrets
Author(s) -
Jackie Pallister,
Deborah Middleton,
Gary Crameri,
Manabu Yamada,
Reuben Klein,
Tim J. Hancock,
Adam J. Foord,
Brian Shiell,
Wojtek P. Michalski,
Christopher C. Broder,
LinFa Wang
Publication year - 2009
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01847-09
Subject(s) - virology , hendra virus , biology , outbreak , virus , chloroquine , ebola virus , malaria , immunology
Hendra virus and Nipah virus, two zoonotic paramyxoviruses in the genusHenipavirus , have recently emerged and continue to cause sporadic disease outbreaks in humans and animals. Mortality rates of up to 75% have been reported in humans, but there are presently no clinically licensed therapeutics for treating henipavirus-induced disease. A recent report indicated that chloroquine, used in malaria therapy for over 70 years, prevented infection with Nipah virus in vitro. Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo.