Virulence Determinants in the PB2 Gene of a Mouse-Adapted H9N2 Virus | Zendy

Qingtao Liu | Zendy; Junqing Huang | Zendy; Yuxin Chen | Zendy; Hongzhi Chen | Zendy; Qunhui Li | Zendy; Liang He | Zendy; Xiaoli Hao | Zendy; Jingjing Liu | Zendy; Min Gu | Zendy; Jiao Hu | Zendy; Xiaoquan Wang | Zendy; Shunlin Hu | Zendy; Xiaowen Liu | Zendy; Xiufan Liu | Zendy

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Virulence Determinants in the PB2 Gene of a Mouse-Adapted H9N2 Virus

Author(s) -

Qingtao Liu,

Junqing Huang,

Yuxin Chen,

Hongzhi Chen,

Qunhui Li,

Liang He,

Xiaoli Hao,

Jingjing Liu,

Min Gu,

Jiao Hu,

Xiaoquan Wang,

Shunlin Hu,

Xiaowen Liu,

Xiufan Liu

Publication year - 2014

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01775-14

Subject(s) - biology , virulence , virology , virus , influenza a virus subtype h5n1 , gene , h5n1 genetic structure , pathogenicity , influenza a virus , viral replication , mutation , genetics , microbiology and biotechnology , polymerase , covid-19 , infectious disease (medical specialty) , disease , medicine , pathology

The molecular bases of adaptation and pathogenicity of H9N2 influenza virus in mammals are largely unknown. Here, we show that a mouse-adapted PB2 gene with a phenylalanine-to-leucine mutation (F404L) mainly contributes to enhanced polymerase activity, replication, and pathogenicity of H9N2 in mice and also increases the virulence of the H5N1 and 2009 pandemic H1N1 influenza viruses. Therefore, we defined a novel pathogenic determinant, providing further insights into the pathogenesis of influenza viruses in mammals.

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