Open AccessTemperature Protects Insect Cells from Infection by Cricket Paralysis Virus
Author(s) -
Randal C. Cevallos,
Peter Sarnow
Publication year - 2010
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01730-09
Subject(s) - biology , heat shock protein , virus , heat shock , virology , insect , shock (circulatory) , pathogen , rna , microbiology and biotechnology , heat stress , cricket , host (biology) , hsp70 , genetics , gene , zoology , botany , medicine
Heat shock is a well-known stress response characterized by a rapid synthesis of a set of proteins which are responsible for protection against stress. We examined the role of temperature on the growth of cricket paralysis virus, a member of the familyDicistroviridae , in insect cells. Heat shock caused an induction of heat shock protein-encoding mRNAs in uninfected cells but not in infected cells. While viral RNA and protein were abundant during heat shock, virion formation was inhibited at higher temperatures. The different susceptibility to pathogens at different temperatures is likely a crucial feature of host-pathogen interaction in cold-blooded animals.