Open AccessEpstein-Barr Virus LMP1-Mediated Oncogenicity
Author(s) -
Liang Wei Wang,
Sizun Jiang,
Benjamin E. Gewurz
Publication year - 2017
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01718-16
Subject(s) - biology , epstein–barr virus , virus , nasopharyngeal carcinoma , virology , immunosuppression , cancer research , immunology , medicine , radiation therapy
Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular, NF-κB. LMP1 has critical roles in Epstein-Barr virus (EBV)-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis, and anti-LMP1 immunotherapy approaches.
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