Open AccessMicroRNAs of Epstein-Barr Virus Control Innate and Adaptive Antiviral Immunity
Author(s) -
Manuel Albanese,
Takanobu Tagawa,
Alexander Buschle,
Wolfgang Hammerschmidt
Publication year - 2017
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01667-16
Subject(s) - biology , microrna , virus , epstein–barr virus , immune system , virology , innate immune system , acquired immune system , immunity , immunology , epstein–barr virus infection , pathogen , gene , genetics
Epstein-Barr virus (EBV) has established lifelong infection in more than 90% of humanity. While infection is usually controlled by the immune system, the human host fails to completely eliminate the pathogen. Several herpesviral proteins are known to act as immunoevasins, preventing or reducing recognition of EBV-infected cells. Only recently were microRNAs of EBV identified to reduce immune recognition further. This Gem summarizes what we know about immunomodulatory microRNAs of herpesviruses.
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