The Epstein-Barr Virus BDLF4 Gene Is Required for Efficient Expression of Viral Late Lytic Genes | Zendy

Takahiro Watanabe | Zendy; Yohei Narita | Zendy; Masahiro Yoshida | Zendy; Yoshitaka Sato | Zendy; Fumi Goshima | Zendy; Hiroshi Kimura | Zendy; Takayuki Murata | Zendy

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The Epstein-Barr Virus BDLF4 Gene Is Required for Efficient Expression of Viral Late Lytic Genes

Author(s) -

Takahiro Watanabe,

Yohei Narita,

Masahiro Yoshida,

Yoshitaka Sato,

Fumi Goshima,

Hiroshi Kimura,

Takayuki Murata

Publication year - 2015

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01604-15

Subject(s) - lytic cycle , biology , gene , epstein–barr virus , virus , gene expression , virology , viral replication , genetics

Epstein-Barr virus (EBV) is a gammaherpesvirus, associated with infectious mononucleosis and various types of malignancy. We focused here on the BDLF4 gene of EBV and identified it as a lytic gene, expressed with early kinetics. Viral late gene expression of the BDLF4 knockout strain was severely restricted; this could be restored by an exogenous supply of BDLF4. These results indicate that BDLF4 is important for the EBV lytic replication cycle, especially in late gene expression.

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