Preclinical Model To Test Human Papillomavirus Virus (HPV) Capsid Vaccines In Vivo Using Infectious HPV/Cottontail Rabbit Papillomavirus Chimeric Papillomavirus Particles | Zendy

Andrés Mejía | Zendy; Timothy D. Culp | Zendy; Nancy M. Cladel | Zendy; Karla K. Balogh | Zendy; Lynn R. Budgeon | Zendy; Christopher B. Buck | Zendy; Neil D. Christensen | Zendy

Open Access

Preclinical Model To Test Human Papillomavirus Virus (HPV) Capsid Vaccines In Vivo Using Infectious HPV/Cottontail Rabbit Papillomavirus Chimeric Papillomavirus Particles

Author(s) -

Andrés Mejía,

Timothy D. Culp,

Nancy M. Cladel,

Karla K. Balogh,

Lynn R. Budgeon,

Christopher B. Buck,

Neil D. Christensen

Publication year - 2006

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01583-06

Subject(s) - capsid , virology , biology , bovine papillomavirus , human papillomavirus , virus like particle , virus , papillomaviridae , cervical cancer , gene , genome , medicine , recombinant dna , genetics , cancer

A human papillomavirus (HPV) vaccine consisting of virus-like particles (VLPs) was recently approved for human use. It is generally assumed that VLP vaccines protect by inducing type-specific neutralizing antibodies. Preclinical animal models cannot be used to test for protection against HPV infections due to species restriction. We developed a model using chimeric HPV capsid/cottontail rabbit papillomavirus (CRPV) genome particles to permit the direct testing of HPV VLP vaccines in rabbits. Animals vaccinated with CRPV, HPV type 16 (HPV-16), or HPV-11 VLPs were challenged with both homologous (CRPV capsid) and chimeric (HPV-16 capsid) particles. Strong type-specific protection was observed, demonstrating the potential application of this approach.

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