Open AccessThe Toll and Imd Pathways Are Not Required for Wolbachia-Mediated Dengue Virus Interference
Author(s) -
Edwige Rancès,
Travis K. Johnson,
Jean Popovici,
Iñaki IturbeOrmaetxe,
Tasnim Zakir,
Coral G. Warr,
Scott L. O’Neill
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01522-13
Subject(s) - wolbachia , biology , dengue fever , dengue virus , drosophila melanogaster , virology , rna interference , aedes aegypti , virus , innate immune system , viral replication , host (biology) , genetics , immune system , gene , rna , ecology , larva
Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virus-blocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.
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