Open AccessNonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase
Author(s) -
Laure Campillo-Gimenez,
Mireille Laforge,
Michèle Fay,
Audrey Brussel,
MarieChristine Cumont,
Valérie Monceaux,
Ousmane M. Diop,
Yves Lévy,
Bruno Hurtrel,
John Zaunders,
Jacques Corbeil,
Carole Elbim,
Jérôme Estaquier
Publication year - 2010
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01496-09
Subject(s) - biology , tlr9 , tlr7 , simian immunodeficiency virus , virology , interferon , lymph , immunology , virus , interferon type i , inflammation , simian , toll like receptor , innate immune system , immune system , gene , gene expression , pathology , genetics , medicine , dna methylation
Divergent Toll-like receptor 7 (TLR7) and TLR9 signaling has been proposed to distinguish pathogenic from nonpathogenic simian immunodeficiency virus infection in primate models. We demonstrate here that increased expression of type I interferon in pathogenic rhesus macaques compared to nonpathogenic African green monkeys was associated with the recruitment of plasmacytoid dendritic cells in the lymph nodes and the presence of an inflammatory environment early after infection, instead of a difference in the TLR7/9 response.