Comprehensive Mutagenesis of Herpes Simplex Virus 1 Genome Identifies UL42 as an Inhibitor of Type I Interferon Induction | Zendy

Maxime Chapon | Zendy; Michelle S. Parvatiyar | Zendy; Saba R. Aliyari | Zendy; Jeffrey Zhao | Zendy; Genhong Cheng | Zendy

Open Access

Comprehensive Mutagenesis of Herpes Simplex Virus 1 Genome Identifies UL42 as an Inhibitor of Type I Interferon Induction

Author(s) -

Maxime Chapon,

Michelle S. Parvatiyar,

Saba R. Aliyari,

Jeffrey Zhao,

Genhong Cheng

Publication year - 2019

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01446-19

Subject(s) - biology , herpes simplex virus , virology , mutagenesis , interferon , genome , interferon type i , virus , mutation , genetics , gene

This work is the first to report the use of a high-throughput mutagenesis method to study the genome of HSV-1. We report three novel viral proteins potentially involved in regulating the host type I interferon response. We describe a novel mechanism by which the viral protein UL42 is able to suppress the production of beta interferon. The tool we introduce in this study can be used to study the HSV-1 genome in great detail to better understand viral gene functions.

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