Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity | Zendy

Hannah L. Turkington | Zendy; Mindaugas Juozapaitis | Zendy; Philip S. Kerry | Zendy; Teresa Aydillo | Zendy; Juan Ayllón | Zendy; Adolfo Garcı́a-Sastre | Zendy; Martin Schwemmle | Zendy; Benjamin G. Hale | Zendy

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Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity

Author(s) -

Hannah L. Turkington,

Mindaugas Juozapaitis,

Philip S. Kerry,

Teresa Aydillo,

Juan Ayllón,

Adolfo Garcı́a-Sastre,

Martin Schwemmle,

Benjamin G. Hale

Publication year - 2015

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01430-15

Subject(s) - biology , interferon , rna , virology , innate immune system , influenza a virus , virus , rig i , antiviral protein , rna binding protein , immunity , gene , genetics , receptor , immune system

We demonstrate that novel bat HL17NL10 and HL18NL11 influenza virus NS1 proteins are effective interferon antagonists but do not block general host gene expression. Solving the RNA-binding domain structures revealed the canonical NS1 symmetrical homodimer, and RNA binding required conserved basic residues in this domain. Interferon antagonism was strictly dependent on RNA binding, and chimeric bat influenza viruses expressing NS1s defective in this activity were highly attenuated in interferon-competent cells but not in cells unable to establish antiviral immunity.

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