Open AccessHow HIV Nef Proteins Hijack Membrane Traffic To Promote Infection
Author(s) -
Cosmo Z. Buffalo,
Yuichiro Iwamoto,
James H. Hurley,
Xuefeng Ren
Publication year - 2019
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01322-19
Subject(s) - biology , endocytic cycle , context (archaeology) , infectivity , virology , viral replication , viral entry , microbiology and biotechnology , viral pathogenesis , virus , immune system , host (biology) , simian immunodeficiency virus , cell , genetics , endocytosis , paleontology
The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of cell surface proteins to disrupt host immunity and promote the viral replication cycle. Nef counteracts host defenses by sequestering and/or degrading its targets via the endocytic and secretory pathways. Nef does this by physically engaging a number of host trafficking proteins.
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