Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection | Zendy

Peng Lin | Zendy; Yuening Cheng | Zendy; Shanshan Song | Zendy; Jianming Qiu | Zendy; Yi Li | Zendy; Zhigang Cao | Zendy; Jiànróng Lǐ | Zendy; Shipeng Cheng | Zendy; Jianke Wang | Zendy

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Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection

Author(s) -

Peng Lin,

Yuening Cheng,

Shanshan Song,

Jianming Qiu,

Yi Li,

Zhigang Cao,

Jiànróng Lǐ,

Shipeng Cheng,

Jianke Wang

Publication year - 2019

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01249-19

Subject(s) - biology , apoptosis , hek 293 cells , transfection , p38 mitogen activated protein kinases , programmed cell death , microbiology and biotechnology , mitochondrion , bcl 2 associated x protein , caspase 3 , protein kinase a , cell culture , kinase , biochemistry , genetics

MEV causes fatal hemorrhagic enteritis in minks. Apoptosis is a cellular mechanism that effectively sacrifices virus-infected cells to maintain homeostasis between the virus and host. In this study, we demonstrated that MEV induces apoptosis bothin vivo andin vitro . Mechanistically, the viral large nonstructural protein NS1 activates p38 MAPK, which leads p53 phosphorylation to mediate the mitochondrial apoptotic pathway but not the death receptor-mediated apoptotic pathway. This is the first report to uncover the mechanism underlying MEV-induced apoptosis.

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