Open AccessSimian Immunodeficiency Virus Infection Induces Expansion of α4β7+and Cytotoxic CD56+NK Cells
Author(s) -
R. Keith Reeves,
Tristan I. Evans,
Jacqueline Gillis,
R. Paul Johnson
Publication year - 2010
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01126-10
Subject(s) - biology , simian immunodeficiency virus , cytotoxic t cell , interleukin 21 , population , interferon gamma , downregulation and upregulation , natural killer cell , nk 92 , immunology , lymph node , virology , cd16 , virus , cancer research , t cell , cd8 , immune system , in vitro , medicine , cd3 , biochemistry , environmental health , gene
Herein we demonstrate that chronic simian immunodeficiency virus (SIV) infection induces significant upregulation of the gut-homing marker α4β7 on macaque NK cells, coupled with downregulation of the lymph node-trafficking marker, CCR7. Interestingly, in naïve animals, α4β7 expression was associated with increased NK cell activation and, on CD16+ NK cells, delineated a unique dual-function cytotoxic-CD107a+ /gamma interferon (IFN-γ)-secreting population. However, while SIV infection increased CD107a expression on stimulated CD56+ NK cells, α4β7+ and α4β7− NK cells were affected similarly. These findings suggest that SIV infection redirects NK cells away from the lymph nodes to the gut mucosae but alters NK cell function independent of trafficking repertoires.