Open AccessKaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence
Author(s) -
Magdalena Weidner-Glunde,
Giuseppe Mariggiò,
Thomas F. Schulz
Publication year - 2017
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01083-16
Subject(s) - biology , virology , persistence (discontinuity) , virus latency , antigen , dna , latency (audio) , kaposi's sarcoma associated herpesvirus , sarcoma , viral replication , virus , herpesviridae , viral disease , immunology , genetics , geotechnical engineering , electrical engineering , engineering , medicine , pathology
Kaposi's sarcoma herpesvirus (KSHV) establishes lifelong latency. The viral latency-associated nuclear antigen (LANA) promotes viral persistence by tethering the viral genome to cellular chromosomes and by participating in latent DNA replication. Recently, the structure of the LANA C-terminal DNA binding domain was solved and new cytoplasmic variants of LANA were discovered. We discuss how these findings contribute to our current view of LANA structure and assembly and of its role during viral persistence.
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