The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication | Zendy

José Luis Martínez | Zendy; Francesca Arnoldi | Zendy; Elisabeth M. Schraner | Zendy; Catherine Eichwald | Zendy; Daniela SilvaAyala | Zendy; Eunjoo H. Lee | Zendy; Elizabeth Sztul | Zendy; Óscar R. Burrone | Zendy; Susana López | Zendy; Carlos F. Arias | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication

Author(s) -

José Luis Martínez,

Francesca Arnoldi,

Elisabeth M. Schraner,

Catherine Eichwald,

Daniela SilvaAyala,

Eunjoo H. Lee,

Elizabeth Sztul,

Óscar R. Burrone,

Susana López,

Carlos F. Arias

Publication year - 2019

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.01062-19

Subject(s) - biology , guanine nucleotide exchange factor , replication (statistics) , guanine , virology , nucleotide , genetics , rotavirus , gene , virus , gtpase

Rotavirus, a member of the familyReoviridae , is the major cause of severe diarrhea in children and young animals worldwide. Despite significant advances in the characterization of the biology of this virus, the mechanisms involved in morphogenesis of the virus particle are still poorly understood. In this work, we show that the guanine nucleotide exchange factor GBF1, relevant for COPI/Arf1-mediated cellular vesicular transport, participates in the replication cycle of the virus, influencing the correct processing of viral glycoproteins VP7 and NSP4 and the assembly of the virus surface proteins VP7 and VP4.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research