Open AccessAtlastin Endoplasmic Reticulum-Shaping Proteins Facilitate Zika Virus Replication
Author(s) -
Blandine Monel,
Maaran Michael Rajah,
Mohamed Lamine Hafirassou,
Samy Sid Ahmed,
Julien BurlaudGaillard,
PengPeng Zhu,
Quentin Nevers,
Julian Buchrieser,
Françoise Porrot,
Cécile Meunier,
Sonia Amraoui,
Maxime Chazal,
Audrey Salles,
Nolwenn Jouvenet,
Philippe Roingeard,
Craig Blackstone,
Ali Amara,
Olivier Schwartz
Publication year - 2019
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01047-19
Subject(s) - endoplasmic reticulum , biology , zika virus , virology , viral replication , microcephaly , microbiology and biotechnology , virus , genetics
Zika virus (ZIKV) is an emerging virus associated with Guillain-Barré syndrome, and fetal microcephaly as well as other neurological complications. There is no vaccine or specific antiviral treatment against ZIKV. We found that endoplasmic reticulum (ER)-shaping atlastin proteins (ATL1, -2, and -3), which induce ER membrane fusion, facilitate ZIKV replication. We show that ATL3 is recruited to the viral replication site and colocalize with the viral proteins NS2A and NS2B3. The results provide insights into host factors used by ZIKV to enhance its replication.
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