Open AccessMammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus
Author(s) -
Ji-Young Min,
Celia Santos,
Adam Fitch,
Alan Twaddle,
Yoshiko Toyoda,
Jay V. DePasse,
Elodie Ghedin,
Kanta Subbarao
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01016-13
Subject(s) - biology , influenza a virus subtype h5n1 , virology , h5n1 genetic structure , gene , adaptation (eye) , influenza a virus , virus , genetics , orthomyxoviridae , avian influenza virus , covid-19 , infectious disease (medical specialty) , medicine , disease , neuroscience , pathology
The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host range determinant for infection of mammals. Here, we report that the E-to-K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along the respiratory tracts of mice and was complete by day 6 postinoculation. This mutation correlated with efficient replication of the virus in mice.
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