Open AccessEvidence of Lymphocytic Choriomeningitis Virus (LCMV) in Domestic Mice in Gabon: Risk of Emergence of LCMV Encephalitis in Central Africa
Author(s) -
Nadine N’dilimabaka,
Nicolás Berthet,
Virginie Rougeron,
Joa Braïthe Mangombi,
Patrick Durand,
Gaël Darren Maganga,
Christiane Bouchier,
Bradley S. Schneider,
Joseph N. Fair,
François Renaud,
Eric M. Leroy
Publication year - 2014
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.01009-14
Subject(s) - lymphocytic choriomeningitis , biology , arenavirus , virology , virus , encephalitis , phylogenetic tree , disease , immunology , gene , genetics , immune system , pathology , cd8 , medicine
Lymphocytic choriomeningitis virus (LCMV) can cause acute fatal disease on all continents but was never detected in Africa. We report the first detection of LCMV RNA in a common European house mouse (Mus musculus domesticus ) in Africa. Phylogenetic analyses show a close relationship with North American strains. These findings suggest that there is a risk of the appearance of LCMV acute encephalitis cases. This is a perfect example of virus dissemination by its natural host that may have dramatic public health consequences.
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