Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection | Zendy

KunWei Chan | Zendy; Ruimin Pan | Zendy; Matthew R. Costa | Zendy; Miroslaw K. Górny | Zendy; Shixia Wang | Zendy; Shan Lu | Zendy; XiangPeng Kong | Zendy

Open Access

Structural Comparison of Human Anti-HIV-1 gp120 V3 Monoclonal Antibodies of the Same Gene Usage Induced by Vaccination and Chronic Infection

Author(s) -

KunWei Chan,

Ruimin Pan,

Matthew R. Costa,

Miroslaw K. Górny,

Shixia Wang,

Shan Lu,

XiangPeng Kong

Publication year - 2018

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00641-18

Subject(s) - biology , epitope , monoclonal antibody , v3 loop , antibody , affinity maturation , virology , vaccination , hiv vaccine , gene , human immunodeficiency virus (hiv) , immunology , aids vaccines , computational biology , genetics , vaccine trial

Understanding the structural basis of gene usage and affinity maturation for anti-HIV-1 antibodies may help vaccine design and development. Antibodies targeting the highly immunogenic third variable loop (V3) of HIV-1 gp120 provide a unique opportunity for detailed structural investigations. By comparing the sequences and structures of four anti-V3 MAbs at different stages of affinity maturation but of the same V gene usage, two induced by vaccination and another two by chronic infection, we provide a fine example of how germ line sequence determines the essential elements for epitope recognition and how affinity maturation improves the antibody's recognition of its epitope.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research