Open AccessGenomic and Phylogenetic Characterization of Brazilian Yellow Fever Virus Strains
Author(s) -
Márcio Roberto Teixeira Nunes,
Gustavo Palacios,
Jedson Ferreira Cardoso,
Livia Carício Martins,
Edivaldo Costa Sousa,
Clayton Pereira Silva de Lima,
Daniele Barbosa de Almeida Medeiros,
Nazir Savji,
Aaloki Desai,
Sueli G. Rodrigues,
Valéria Lima Carvalho,
W. Ian Lipkin,
Pedro Fernando da Costa Vasconcelos
Publication year - 2012
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00565-12
Subject(s) - biology , phylogenetic tree , genotype , phylogeography , genome , yellow fever , virus , virology , phylogenetics , biological dispersal , genetics , evolutionary biology , gene , population , demography , sociology
Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3' noncoding region (3'NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findings suggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.
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