A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts | Zendy

Shoaleh Dehghan | Zendy; Jason Seto | Zendy; Elizabeth B. Liu | Zendy; Ashrafali Mohamed Ismail | Zendy; Ramana Madupu | Zendy; Albert Heim | Zendy; Morris S. Jones | Zendy; David W. Dyer | Zendy; James Chodosh | Zendy; Donald Seto | Zendy

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A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts

Author(s) -

Shoaleh Dehghan,

Jason Seto,

Elizabeth B. Liu,

Ashrafali Mohamed Ismail,

Ramana Madupu,

Albert Heim,

Morris S. Jones,

David W. Dyer,

James Chodosh,

Donald Seto

Publication year - 2019

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00564-19

Subject(s) - biology , zoonosis , virology , simian , human pathogen , genome , bonobo , pathogen , genetics , transmission (telecommunications) , recombination , virus , gene , ecology , electrical engineering , engineering

An emergent adenoviral human pathogen, HAdV-B76, associated with a fatality in 1965, shows a remarkable degree of genome identity with two recently isolated simian adenoviruses that contain cross-species genome recombination events from three hosts: human, chimpanzee, and bonobo. Zoonosis (nonhuman-to-human transmission) and anthroponosis (human to nonhuman transmission) may play significant roles in the emergence of human adenoviral pathogens.

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