Gallid Herpesvirus 1 Initiates Apoptosis in Uninfected Cells through Paracrine Repression of p53 | Zendy

Hai Li | Zendy; Qi Gao | Zendy; Yuhao Shao | Zendy; Bangyao Sun | Zendy; Fengjie Wang | Zendy; Yangyang Qiao | Zendy; Nana Wang | Zendy; Shengwang Liu | Zendy

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Gallid Herpesvirus 1 Initiates Apoptosis in Uninfected Cells through Paracrine Repression of p53

Author(s) -

Hai Li,

Qi Gao,

Yuhao Shao,

Bangyao Sun,

Fengjie Wang,

Yangyang Qiao,

Nana Wang,

Shengwang Liu

Publication year - 2018

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00529-18

Subject(s) - biology , paracrine signalling , apoptosis , viral replication , microbiology and biotechnology , psychological repression , virology , mechanism (biology) , in vivo , virus , host (biology) , genetics , gene , gene expression , receptor , philosophy , epistemology

It is well accepted that herpesviruses suppress the apoptosis of host cells via various strategies to ensure sustained viral replication during infection. However, a recentin vivo study reported the apoptosis of remote uninfected cells during GaHV-1 infection. The mechanism and the biological meaning of this unexpected herpesvirus-host interaction are unclear. This study uncovers the mechanisms of herpesvirus-triggered apoptosis in uninfected cells and may also contribute to a mechanistic illustration of paracrine-regulated apoptosis induced by other viruses in uninfected host cells.

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