TAF Family Proteins and MEF2C Are Essential for Epstein-Barr Virus Super-Enhancer Activity | Zendy

Chong Wang | Zendy; Sizun Jiang | Zendy; Luyao Zhang | Zendy; Difei Li | Zendy; Jun Liang | Zendy; Yohei Narita | Zendy; Isabella Hou | Zendy; Qian Zhong | Zendy; Benjamin E. Gewurz | Zendy; Mingxiang Teng | Zendy; Bo Zhao | Zendy

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TAF Family Proteins and MEF2C Are Essential for Epstein-Barr Virus Super-Enhancer Activity

Author(s) -

Chong Wang,

Sizun Jiang,

Luyao Zhang,

Difei Li,

Jun Liang,

Yohei Narita,

Isabella Hou,

Qian Zhong,

Benjamin E. Gewurz,

Mingxiang Teng,

Bo Zhao

Publication year - 2019

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00513-19

Subject(s) - biology , enhancer , mef2c , genetics , epstein–barr virus , virology , virus , computational biology , transcription factor , gene

SEs play critical roles in cancer development. Since SEs assemble much bigger protein complexes on enhancers than typical enhancers (TEs), they are more sensitive than TEs to perturbations. Understanding the protein composition of SEs that are linked to key oncogenes may identify novel therapeutic targets. A genome-wide CRISPR screen specifically identified proteins essential for MYC ESE activity but not simian virus 40 (SV40) enhancer. These proteins not only were essential for the reporter activity but also were also important for MYC expression and LCL growth. Targeting these proteins may lead to new therapies for EBV-associated cancers.

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