Open AccessHerpes Simplex Virus 1 Coinfection Modifies Adeno-associated Virus Genome End Recombination
Author(s) -
Anita F. Meier,
Kurt Tobler,
Kevin Michaelsen,
Bernd Vogt,
Els Henckaerts,
Cornel Fraefel
Publication year - 2021
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00486-21
Subject(s) - biology , herpes simplex virus , virology , adeno associated virus , coinfection , virus , helper virus , genetic enhancement , genome , vector (molecular biology) , gene , genetics , viral replication , recombinant dna
Adeno-associated virus (AAV)-mediated gene therapy represents one of the most promising approaches for the treatment of genetic diseases. Currently, various GMP-compatible production methods can be applied to manufacture clinical-grade vector, including methods that employ helper factors derived from herpes simplex virus 1 (HSV-1).