The Kinetics of Hepatitis C Virus-Specific CD8 T-Cell Responses in the Blood Mirror Those in the Liver in Acute Hepatitis C Virus Infection | Zendy

EuiCheol Shin | Zendy; Stefania Capone | Zendy; Riccardo Cortese | Zendy; Stefano Colloca | Zendy; Alfredo Nicosia | Zendy; Antonella Folgori | Zendy; Barbara Rehermann | Zendy

Open Access

The Kinetics of Hepatitis C Virus-Specific CD8 T-Cell Responses in the Blood Mirror Those in the Liver in Acute Hepatitis C Virus Infection

Author(s) -

EuiCheol Shin,

Stefania Capone,

Riccardo Cortese,

Stefano Colloca,

Alfredo Nicosia,

Antonella Folgori,

Barbara Rehermann

Publication year - 2008

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00475-08

Subject(s) - hepatitis c virus , biology , cd8 , virology , immunology , t cell , virus , hepacivirus , hepatitis c , cytotoxic t cell , cell , immune system , in vitro , biochemistry , genetics

Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity.

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