CD4 and CD8 T Cells Directly Recognize Murine Gammaherpesvirus 68-Immortalized Cells and Prevent Tumor Outgrowth | Zendy

Xiaozhan Liang | Zendy; Rebecca L. Crepeau | Zendy; Weijun Zhang | Zendy; Samuel H. Speck | Zendy; Edward J. Usherwood | Zendy

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CD4 and CD8 T Cells Directly Recognize Murine Gammaherpesvirus 68-Immortalized Cells and Prevent Tumor Outgrowth

Author(s) -

Xiaozhan Liang,

Rebecca L. Crepeau,

Weijun Zhang,

Samuel H. Speck,

Edward J. Usherwood

Publication year - 2013

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00375-13

Subject(s) - biology , cytotoxic t cell , cd8 , immortalised cell line , epstein–barr virus , interleukin 21 , cell culture , virology , virus , immunology , microbiology and biotechnology , in vitro , cancer research , immune system , genetics

There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, γHV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.

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