Open AccessInterferon-Inducible MicroRNA miR-128 Modulates HIV-1 Replication by Targeting TNPO3 mRNA
Author(s) -
Aurore Bochnakian,
Anjie Zhen,
Dimitrios G. Zisoulis,
Adam Idica,
Vineet N. KewalRamani,
Nicholas Neel,
Iben Daugaard,
Matthias Hamdorf,
Scott G. Kitchen,
Kyeongeun Lee,
Irene M. Pedersen
Publication year - 2019
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00364-19
Subject(s) - biology , viral replication , jurkat cells , gene knockdown , microbiology and biotechnology , microrna , virology , interferon , virus , cell culture , gene , genetics , t cell , immune system
HIV-1 is the causative agent of AIDS. During HIV-1 infection, type I interferons (IFNs) are induced, and their effectors limit HIV-1 replication at multiple steps in its life cycle. However, the cellular targets of INFs are still largely unknown. In this study, we identified the interferon-inducible microRNA (miR) miR-128, a novel antiviral mediator that suppresses the expression of the host gene TNPO3, which is known to modulate HIV-1 replication. Notably, we observe that anti-miR-128 partly neutralizes the IFN-mediated block of HIV-1. Elucidation of the mechanisms through which miR-128 impairs HIV-1 replication may provide novel candidates for the development of therapeutic interventions.
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