Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env | Zendy

Sai Priya Anand | Zendy; Jonathan R. Grover | Zendy; William D. Tolbert | Zendy; Jérémie Prévost | Zendy; Jonathan Richard | Zendy; Shilei Ding | Zendy; Sophie Baril | Zendy; Halima Medjahed | Zendy; David T. Evans | Zendy; Marzena Pazgier | Zendy; Walther Mothes | Zendy; Andrés Finzi | Zendy

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Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env

Author(s) -

Sai Priya Anand,

Jonathan R. Grover,

William D. Tolbert,

Jérémie Prévost,

Jonathan Richard,

Shilei Ding,

Sophie Baril,

Halima Medjahed,

David T. Evans,

Marzena Pazgier,

Walther Mothes,

Andrés Finzi

Publication year - 2019

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.00293-19

Subject(s) - internalization , antibody dependent cell mediated cytotoxicity , antibody , biology , gp41 , glycoprotein , virology , immune system , microbiology and biotechnology , flow cytometry , neutralizing antibody , cytotoxicity , in vitro , cell , epitope , monoclonal antibody , immunology , biochemistry

HIV-1 has evolved to acquire several strategies to limit the exposure of its envelope glycoproteins (Env) on the surface of infected cells. In this study, we show that antibody-induced Env internalization is conformation specific and reduces the susceptibility of infected cells to antibody-dependent cellular cytotoxicity (ADCC). Thus, a better understanding of this mechanism might help develop antibodies with improved capacities to mediate ADCC.

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