Open AccessSubstitutions T200A and E227A in the Hemagglutinin of Pandemic 2009 Influenza A Virus Increase Lethality but Decrease Transmission
Author(s) -
Carles MartínezRomero,
Erik de Vries,
Alan BelichaVillanueva,
Ignacio Mena,
Donna M. Tscherne,
Virginia Gillespie,
Randy A. Albrecht,
Cornelis A. M. de Haan,
Adolfo Garcı́a-Sastre
Publication year - 2013
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00262-13
Subject(s) - hemagglutinin (influenza) , biology , virology , virus , lethality , transmission (telecommunications) , pathogenesis , pandemic , h5n1 genetic structure , viral replication , influenza a virus , viral pathogenesis , genetics , immunology , disease , covid-19 , infectious disease (medical specialty) , medicine , electrical engineering , engineering , pathology
We report that swine influenza virus-like substitutions T200A and E227A in the hemagglutinin (HA) of the 2009 pandemic influenza virus alter its pathogenesis and transmission. Viral replication is increased in mammalian cells. Infected mice show increased disease as measured by weight loss and lethality. Transmission in ferrets is decreased in the presence of both substitutions, suggesting that amino acids 200T and 227E are adaptive changes in the HA of swine origin influenza viruses associated with increased transmission and decreased pathogenesis.
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