Open AccessCytomegalovirus e127 Protein Interacts with the Inhibitory CD200 Receptor
Author(s) -
Mildred Foster-Cuevas,
Tina Westerholt,
Mohamed I. M. Ahmed,
Marion H. Brown,
A. Neil Barclay,
Sebastian Voigt
Publication year - 2011
Publication title -
journal of virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.617
H-Index - 292
eISSN - 1070-6321
pISSN - 0022-538X
DOI - 10.1128/jvi.00064-11
Subject(s) - biology , glycoprotein , receptor , virus , cell , cytomegalovirus , microbiology and biotechnology , virology , membrane glycoproteins , inhibitory postsynaptic potential , downregulation and upregulation , herpesviridae , gene , biochemistry , viral disease , neuroscience
CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus.