Open AccessUnique NS5b Hepatitis C Virus Gene Sequence Consensus Database Is Essential for Standardization of Genotype Determinations in Multicenter Epidemiological Studies
Author(s) -
Syria Laperche,
Karine Sauné,
Paul Dény,
Gilles Duverlie,
Sophie Alain,
MarieLaure Chaix,
Catherine Gaudy,
F. Lunel,
Jean–Michel Pawlotsky,
Christopher Payan,
Bruno Pozzetto,
Catherine Tamalet,
Vincent Thibault,
Sophie Vallet,
Françoise Bouchardeau,
Jacques Izopet,
JeanJacques Lefrère
Publication year - 2006
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.44.2.614-616.2006
Subject(s) - genotype , epidemiology , virology , multicenter study , ns5b , standardization , hepatitis c virus , biology , molecular epidemiology , medicine , hepacivirus , virus , genetics , gene , computer science , randomized controlled trial , operating system
A multicenter study of NS5b hepatitis C virus (HCV) genotype determination involving 12 laboratories demonstrates that any laboratory with expertise in sequencing techniques would be able to provide a reliable HCV genotype for clinical and epidemiological purposes as long as they are provided a consensus reference sequence database.