Use of a New Dual-Antigen Enzyme-Linked Immunosorbent Assay To Detect and Characterize the Human Antibody Response to the Human Immunodeficiency Virus Type 2 Envelope gp125 and gp36 Glycoproteins | Zendy

José Maria Marcelino | Zendy; Helena Barroso | Zendy; Fátima Gonçalves | Zendy; Sofia M. da Silva | Zendy; Carlos Novo | Zendy; Perpétua Gómes | Zendy; Ricardo Camacho | Zendy; Nuno Taveira | Zendy

Open Access

Use of a New Dual-Antigen Enzyme-Linked Immunosorbent Assay To Detect and Characterize the Human Antibody Response to the Human Immunodeficiency Virus Type 2 Envelope gp125 and gp36 Glycoproteins

Author(s) -

José Maria Marcelino,

Helena Barroso,

Fátima Gonçalves,

Sofia M. da Silva,

Carlos Novo,

Perpétua Gómes,

Ricardo Camacho,

Nuno Taveira

Publication year - 2006

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.44.2.607-611.2006

Subject(s) - virology , antigen , glycoprotein , recombinant dna , biology , antibody , human immunodeficiency virus (hiv) , virus , enzyme , envelope (radar) , viral envelope , immunology , microbiology and biotechnology , biochemistry , gene , telecommunications , radar , computer science

A dual-antigen enzyme-linked immunosorbent assay specific for human immunodeficiency virus type 2 (HIV-2) envelope proteins, ELISA-HIV2, was developed with two new recombinant polypeptides, rpC2-C3 and rgp36, derived from the HIV-2 envelope. The diagnostic performance was determined with HIV-2, HIV-1, and HIV-1/2 samples. Both polypeptides showed 100% specificity. Clinical sensitivity was 100% for rgp36 and 93.4% for rpC2-C3. ELISA-HIV2 may be used for the specific diagnosis and confirmation of HIV-2 infection.

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