Open AccessDemonstration of a High Level of Parasite Population Homology by Quantification of Plasmodium falciparum Alleles in Matched Peripheral, Placental, and Umbilical Cord Blood Samples
Author(s) -
Sayeh Jafari-Guemouri,
Nicaise Tuikue Ndam,
Gwladys Bertin,
Emily Renart,
Sokhna Sow,
Jean-Yves Le Hesran,
Philippe Deloron
Publication year - 2005
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.43.6.2980-2983.2005
Subject(s) - parasite hosting , biology , plasmodium falciparum , umbilical cord , allele , multiplicity of infection , population , genetics , gene , immunology , virology , malaria , medicine , environmental health , world wide web , computer science
Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought.