Open AccessClonal Spread of Pediatric Isolates of Ciprofloxacin-Resistant, emm Type 6 Streptococcus pyogenes
Author(s) -
Rodrigo Alonso,
Estíbaliz Mateo,
Marc Galimand,
Javier Garaizar,
Patrice Courvalin,
R Cisterna
Publication year - 2005
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.43.5.2492-2493.2005
Subject(s) - gatifloxacin , streptococcus pyogenes , moxifloxacin , ciprofloxacin , levofloxacin , microbiology and biotechnology , streptococcus suis , biology , quinolone , multilocus sequence typing , virology , genotype , antibiotics , gene , bacteria , genetics , staphylococcus aureus , virulence
Twenty-four community isolates of Streptococcus pyogenes resistant to ciprofloxacin and susceptible to levofloxacin, gatifloxacin, and moxifloxacin were studied. Sequence determination of the quinolone resistance-determining regions in the gyrA and parC genes revealed a T/G mutation in parC leading to a Ser79Ala substitution in ParC. All isolates were of the emm type 6, and 18 and 2 of them were indistinguishable or closely related, respectively, on the basis of pulsed-field gel electrophoresis.