Open AccessIn Vitro Activities of Anidulafungin against More than 2,500 Clinical Isolates of Candida spp., Including 315 Isolates Resistant to Fluconazole
Author(s) -
Michael A. Pfaller,
L. Boyken,
Richard J. Hollis,
S. A. Messer,
S. Tendolkar,
Daniel J. Diekema
Publication year - 2005
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.43.11.5425-5427.2005
Subject(s) - anidulafungin , fluconazole , microbiology and biotechnology , broth microdilution , echinocandin , echinocandins , candida parapsilosis , biology , candida glabrata , candida krusei , candida albicans , candida tropicalis , corpus albicans , minimum inhibitory concentration , antifungal , antimicrobial , caspofungin
Anidulafungin is an echinocandin antifungal agent with potent activity againstCandida spp. We assessed the in vitro activity of anidulafungin against 2,235 clinical isolates ofCandida spp. using the CLSI broth microdilution method. Anidulafungin was very active againstCandida spp. (the MIC at which 90% of strains are inhibited [MIC90 ] was 2 μg/ml when MIC endpoint criteria of partial inhibition [MIC-2] were used).Candida albicans ,C. glabrata ,C. tropicalis ,C. krusei , andC. kefyr were the most susceptible species ofCandida (MIC90 , 0.06 to 0.12 μg/ml), andC. parapsilosis ,C. lusitaniae , andC. guilliermondii were the least susceptible (MIC90 , 0.5 to 2 μg/ml). In addition, 315 fluconazole-resistant isolates were tested, and 99% were inhibited by ≤1 μg/ml of anidulafungin. These results provide further evidence for the spectrum and potency of anidulafungin activity against a large and geographically diverse collection of clinically important isolates ofCandida spp.