Open AccessIn Vivo Acquisition of High-Level Resistance to Imipenem in Escherichia coli
Author(s) -
Laurent Poirel,
Claire Héritier,
C. Spicq,
Patrice Nordmann
Publication year - 2004
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.42.8.3831-3833.2004
Subject(s) - imipenem , escherichia coli , cephalosporin , microbiology and biotechnology , bacterial outer membrane , plasmid , biology , enterobacteriaceae , antibiotics , antibiotic resistance , gene , genetics
Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.