Open AccessFirst Molecular Identification of Human Dobrava Virus Infection in Central Europe
Author(s) -
Boris Klempa,
M. Schütt,
Brita Auste,
М Лабуда,
Rainer G. Ulrich,
Helga Meisel,
Detlev H. Krüger
Publication year - 2004
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.42.3.1322-1325.2004
Subject(s) - virology , hantavirus , apodemus agrarius , biology , virus , strain (injury) , rodent , ecology , anatomy
Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava hantavirus (DOBV). This is the first molecular identification of human infection by DOBV in central Europe and the first proof that a virus strain related to the DOBV-Aa lineage, carried by Apodemus agrarius rodents, is able to cause HFRS.