Open AccessMolecular Epidemiology of Haemophilus influenzae Type b Isolated from Children with Clinical Cases of Conjugate Vaccine Failures
Author(s) -
José Campos,
Belén Aracil,
Federico Román,
María PérezVázquez
Publication year - 2003
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.41.8.3915-3918.2003
Subject(s) - haemophilus influenzae , pasteurellaceae , conjugate vaccine , microbiology and biotechnology , virology , vaccine failure , antibody , epidemiology , conjugate , molecular epidemiology , biology , hib vaccine , haemophilus , medicine , immunization , immunology , bacteria , genotype , genetics , antibiotics , gene , mathematical analysis , mathematics
We analyzed eight invasive Haemophilus influenzae strains isolated from individual children vaccinated appropriately for their ages. Five of the strains were type b and three were nontypeable strains. Children infected with nontypeable strains had a protective level of anti-H. influenzae type b antibodies, while only one of the children whose cases represented true vaccine failure did.