Open AccessProspective Clinical Evaluation of the Serologic Tuberculous Glycolipid Test in Combination with the Nucleic Acid Amplification Test
Author(s) -
Ryoji Maekura,
Hiroaki Kohno,
Atsushi Hirotani,
Yoshinari Okuda,
Masami Ito,
Takeshi Ogura,
Ikuya Yano
Publication year - 2003
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.41.3.1322-1325.2003
Subject(s) - tuberculosis , serology , medicine , glycolipid , prospective cohort study , nucleic acid test , nucleic acid , immunology , pathology , biology , antibody , disease , covid-19 , infectious disease (medical specialty) , biochemistry
We have conducted a prospective controlled multicenter study to evaluate differences in the levels of clinical utility of the tuberculous glycolipid (TBGL) serodiagnostic test and the nucleic acid amplification test in patients with smear-negative active pulmonary tuberculosis (TB). The TBGL test and the PCR test were individually not so useful for the rapid diagnosis of smear-negative active pulmonary TB. However, clinical utility was considerably improved by using the TBGL test and the PCR test in combination, especially in patients with smear-negative and culture-negative active pulmonary TB and in patients with minimally advanced lesions.