Open AccessCaspofungin Activity against Clinical Isolates of Fluconazole-Resistant Candida
Author(s) -
Michael A. Pfaller,
S. A. Messer,
L. Boyken,
C. Rice,
S. Tendolkar,
Richard J. Hollis,
Daniel J. Diekema
Publication year - 2003
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.41.12.5729-5731.2003
Subject(s) - fluconazole , caspofungin , microbiology and biotechnology , biology , fungi imperfecti , echinocandins , antifungal
A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml).